David Emanuel Twiggs (1790 – July 15, 1862) was a United States soldier during the War of 1812 and Mexican-American War and a general of the Confederate States Army during the American Civil War.
Twiggs was born on the "Good Hope" estate in Richmond County, Georgia, son of John Twiggs, a general in the Georgia militia during the American Revolution. Twiggs volunteered for service in the War of 1812 and subsequently served in the Seminole Wars and the Black Hawk War.
He was Colonel of the 2nd U.S. Dragoons at the outbreak of the Mexican-American War. He led brigade in the Army of Occupation at the battles of Palo Alto and Resaca de la Palma. He was promoted to brigadier general and commanded a division at the Battle of Monterrey. He joined Winfield Scott's expedition, commanding its 2nd Division of Regulars and led the division in all the battles from Veracruz through Mexico City. He was wounded during the assault on Chapultepec. After the fall of Mexico City he was appointed military governor of Veracruz. He was awarded a ceremonial sword by the Congress on March 2, 1847. (The sword was recovered when New Orleans was captured in 1862 and returned to the Twiggs family in 1889.)
After the Mexican War, Twiggs was appointed brevet major general and commanded the Department of Texas. He was in this command when the Civil War broke out. Twiggs's command included about 20% of the U.S. Army guarding the border of the U.S. and Mexico. As the states began to secede, Twiggs voluntarily turned over his entire command to the Confederacy and defected on February 19, 1861. He was dismissed from the U.S. Army for treason and accepted a commission as a major general by the Confederate States. He was appointed to command the Confederate Department of Louisiana, but his age kept him from active command and he retired on October 11, 1861. He died of pneumonia in Augusta, Georgia, and is buried at "Good Hope".